Ofatumumab (trade name Arzerra, also known as HuMax-CD20) is a fully human monoclonal antibody (for the CD20 protein) which appears to inhibit early-stage B lymphocyte activation. It is FDA approved for treating chronic lymphocytic leukemia that is refractory to fludarabine and alemtuzumab (Campath) and has also shown potential in treating follicular lymphoma, diffuse large B cell lymphoma, rheumatoid arthritis and relapsing remitting multiple sclerosis...Wikipedia

Manufacturer's Website: Arzerra

Average retail cost: $580/vial

Rituximab, sold under the brand name Rituxan among others, is a medication used to treat certain autoimmune diseases and types of cancer. It is used for non-Hodgkin's lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, idiopathic thrombocytopenic purpura, pemphigus vulgaris and myasthenia gravis. It is given by slow injection into a vein...Wikipedia

Manufacturer's Website: Rituxan

Average retail cost: $900/vial

Tositumomab is a murine IgG2a lambda monoclonal antibody directed against the CD20 antigen, produced in mammalian cells. Combined with radioisotope iodine 131 it was called Iodine I 131 Tositumomab. Unlabelled tositumomab together with iodine-labelled tositumomab was called Bexxar and a personalized regimen using Bexxar was approved for the treatment of relapsed or chemotherapy/rituxan-refractory Non-Hodgkin lymphoma in 2003....Wikipedia

Bexxar is no longer manufactured

and there is no generic available.

Obinutuzumab (called afutuzumab until 2009, originally GA101) is a humanized anti-CD20 monoclonal antibody, originated by GlycArt Biotechnology AG and developed by Roche as a cancer treatment. It was approved under the trade name Gazyva by the US FDA in 2013, and as Gazyvaro by the EMA in Europe, for the treatment of chronic lymphocytic leukemia in combination with chemotherapy in treatment-naive patients, and as a second line treatment for follicular lymphoma...Wikipedia

Manufacturer's Website: Gazyva

Average retail cost: *

* This prescription is provided by your healthcare provider. It cannot be filled in a pharmacy and may be expensive.

Ocrelizumab (trade name Ocrevus) is a humanized anti-CD20 monoclonal antibody. It targets CD20 marker on B lymphocytes and hence is an immunosuppressive drug candidate. Ocrelizumab binds to an epitope that overlaps with the epitope to which rituximab binds....Wikipedia

Manufacturer's Website: Ocrevus

Average retail cost: *

* This prescription is provided by your healthcare provider. It cannot be filled in a pharmacy and may be expensive.

RITUXAN HYCELA™ (rituximab/hyaluronidase human) is a prescription medicine used to treat adults with:

1) Follicular Lymphoma (FL) as a single-agent therapy in patients whose disease recurred or did not respond to initial treatment

2) Follicular Lymphoma as an initial treatment with chemotherapy and, in patients whose initial treatment was successful, as a single-agent follow-up therapy

3) Follicular Lymphoma as a single agent follow-up therapy for patients who did not progress on initial treatment with CVP chemotherapy

4) Diffuse Large B-Cell Lymphoma (DLBCL) as an initial treatment in combination with CHOP or other anthracycline-based chemotherapy regimens

5) Chronic Lymphocytic Leukemia (CLL) in combination with FC chemotherapy as an initial treatment or as a treatment after disease has recurred

Manufacturer's Website: Rituxan Hycela

Average retail cost: *

* This prescription is provided by your healthcare provider. It cannot be filled in a pharmacy and may be expensive.

Ibritumomab tiuxetan, sold under the trade name Zevalin, is a monoclonal antibody radioimmunotherapy treatment for relapsed or refractory, low grade or transformed B cell non-Hodgkin's lymphoma, a lymphoproliferative disorder...Wikipedia

Manufacturer's Website: Zevalin

Average retail cost: *

* This prescription is provided by your healthcare provider. It cannot be filled in a pharmacy and may be expensive.