Hedgehog Pathway Inhibitors

Sonidegib (INN), also known as LDE225 and marketed as Odomzo, is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) being developed as an anticancer agent by Novartis. It was approved by the FDA for treating basal-cell carcinoma in July 2015 and is awaiting approval in the EU. In the EU, the agent has received positive opinion from the CHMP for approval...Wikipedia

Manufacturer's Website: Odomzo                                                                    Average retail cost: $10,300/vial

Vismodegib (trade name Erivedge) is a drug for the treatment of basal-cell carcinoma (BCC). The approval of vismodegib on January 30, 2012, represents the first Hedgehog signaling pathway targeting agent to gain U.S. Food and Drug Administration (FDA) approval...Wikipedia

Manufacturer's Website: Erivedge                                                                  Average retail cost: $11,800/vial

Glasdegib (PF-04449913) is an FDA approved cancer drug developed by Pfizer. It is a small molecule inhibitor of sonic hedgehog, which is a protein overexpressed in many types of cancer. It inhibits the sonic hedgehog receptor smoothened (SMO), as do most drugs in its class...Wikipedia

Manufacturer's Website: Daurismo                                                            Average retail cost: $16,000/month